General Information

  • ID:  hor001596
  • Uniprot ID:  Q07981
  • Protein name:  NDPFLRF-amide
  • Gene name:  NA
  • Organism:  Cornu aspersum (Brown garden snail) (Helix aspersa)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  Central nervous system.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Cornu (subgenus), Cornu (genus), Helicidae (family), Helicoidea (superfamily), Helicina, Stylommatophora (order), Eupulmonata (superorder), Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  NDPFLRF
  • Length:  7(50-56)
  • Propeptide:  MTSLCLTIAPAVLSLICLSSYGWAEGDTTDNEYLRFGRENNNGYIRFGRNDPFLRFGKKSDPFLRFGKQDPFLRIGRQDPFLRFGKQDPFLRFGKQDPFLRIGKQDPFLRFGRSEPYLRFGRNDPYLRFGRNDPYLRFGRNDPYLRFGRNDPYLRFGKNDPFLRFGKSVDGEIEAGVDAVTLSREHEFAHENAASDRQKRSAYTDAIDKDNSLTSLVREAREASDSNGQINDGKVVEVPVFRDTRNGHYMRFGKK
  • Signal peptide:  MTSLCLTIAPAVLSLICLS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Can function as both cardioregulatory hormones and transmitters and may regulate cardiovascular function.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q07981-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001596_AF2.pdbhor001596_ESM.pdb

Physical Information

Mass: 101522 Formula: C43H61N11O11
Absent amino acids: ACEGHIKMQSTVWY Common amino acids: F
pI: 6.34 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: -52.86 Boman Index: -1940
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 55.71
Instability Index: 6360 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  NA
  • Title:  NA